Rabies Post Exposure Prophylaxis Without Immunoglobulin

The wound should be treated in a timely and correct manner, strictly disinfected, the risk of the wound should be assessed. Then rabies vaccine should be vaccinated according to the results. Five-dose rabies vaccine should be carried out on D 0-3-7-14-28 respectively. 

Human rabies immune globulin (HRIG) is the IgG fraction of plasma from human donors who have received multiple doses of rabies vaccine and have high levels of anti-rabies antibody. HRIG is administered once to previously unvaccinated persons exposed to a rabid animal to provide rabies virus neutralizing antibody coverage until the patient responds to vaccination by actively producing virus-neutralizing antibodies. HRIG is administered once on day 0 at the time postexposure prophylaxis (PEP) is initiated, in conjunction with human rabies vaccine. If HRIG was not administered when vaccination was begun on day 0, it can be administered up to and including day 7 of the PEP series.